Sensorimotor Connectivity in Parkinson’s Disease: The Role of Functional Neuroimaging
نویسندگان
چکیده
The diagnosis of Parkinson's disease (PD) remains still clinical; nevertheless, in the last decades, the rapid evolution of advanced MRI techniques has made it possible to detect structural and, increasingly, functional brain changes in patients with PD. Indeed, functional MRI (fMRI) techniques have offered the opportunity to directly measure the brain's activity and connectivity in patients with PD both in early and complicated stage of the disease. The aims of the following review are (1) to present an overview of recent fMRI reports investigating the activity and connectivity of sensorimotor areas in patients with PD using both task-related and "resting-state" fMRI analysis (2) to elucidate potential pathophysiological mechanisms underlying dyskinetic motor complications in the advanced stage of PD.
منابع مشابه
Op-brai130007 1..16
Brain activity during rest is characterized by slow (0.01–0.1 Hz) fluctuations of blood oxygenation level-dependent functional magnetic resonance imaging signals. These fluctuations are organized as functional connectivity networks called resting-state networks, anatomically corresponding to specific neuronal circuits. As Parkinson’s disease is mainly characterized by a dysfunction of the senso...
متن کاملOp-brai130015 1..2
Sir, we would like to comment on a recent article published in Brain by Hacker et al. (2012), which reported functional connectivity alteration in 13 patients with Parkinson’s disease in the medicated state compared with healthy control subjects. Although the authors showed very interesting results, they could not disentangle the effects of levodopa within the patient group. We investigated the...
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